China-Nepal Railway

China-Nepal Railway aims to connect China’s Tibet Autonomous Region (specifically Shigatse, an extension of the existing Qinghai-Tibet Railway) with Kathmandu, the capital of Nepal. It’s envisioned as a “game-changer” for Nepal, transforming it from a landlocked to a “land-linked” country and enhancing connectivity with China and South Asia. The railway passes through the Himalayas, which presents immense engineering challenges. The China-Nepal Railway will involve a significant amount of tunneling, especially on the Nepalese side, due to the challenging Himalayan terrain.

Nepalese Section: The 72.25 km (44.89 mi) Nepalese section of the railway is particularly demanding. Estimates suggest that 95% to 98.5% of this section will consist of bridges or tunnels.

Overall Tunneling: While specific total tunnel lengths vary in reports, some sources indicate that the entire China-Nepal Railway, which has a total length of approximately 540-599 km, will have a very high proportion of tunnels and bridges. One source states that out of the total length of the railway, a staggering 540 kilometers are comprised of bridges and tunnels.

Himalayas Tunnel: A major part of the project includes the “Himalayas Tunnel,” which is expected to be approximately 30 kilometers long. Due to the extreme elevation changes and complex geology. This is why China’s “Jinghua” tunnel boring machine is crucial to the project.

Feasibility Study: A detailed feasibility study for the project is underway. The first phase was completed between March 2023 and January 2024, and a second phase began in March 2024. Ground surveying is estimated to be 60% complete as of late November 2024. The geological prospecting work is expected to be completed by June 2025, and the overall feasibility study is anticipated to be completed in 2026.

Construction: While the project has been agreed upon, actual construction, particularly on the more challenging Nepalese side, has not yet fully commenced. The Chinese section of the railway (Shigatse-Gyirong) is planned to start construction in 2025 and could open around 2030.

Funding: A major hurdle is the funding for the Nepalese section, which is estimated to cost billions of dollars (between US$2.7 billion and US$5.5 billion) – a significant amount compared to Nepal’s annual economic output. Nepal is reportedly unable to bear the full cost, and there are discussions and concerns about whether China will provide grant arrangements or loans.

While the China-Nepal Railway will traverse very high altitudes, the existing Qinghai-Tibet Railway in China already holds the record for the world’s highest railway, reaching a peak of 5,068 meters (16,627 ft) at Tanggula Pass. The China-Nepal railway is an extension of this existing high-altitude network. India also has the Chenab Bridge, which is the world’s highest railway bridge (359 meters above the riverbed) and was completed and inaugurated in August 2022, with full use expected by April 2025.

The “Jinghua” is an extra-large tunnel boring machine (TBM) with independent intellectual property rights, manufactured in China. It is also referred to as the largest earth pressure balance (EPB) tunnel boring machine.

Size and Weight: It has an excavation diameter of 12.79 meters, is 135 meters long, and weighs 3,000 tons.

Power: It has an installed power of 7,500 kilowatts (kW).

Cutter Head: It features an eight-spoke heavy-duty cutter head equipped with 19-inch cutters, capable of boring through rocks and dirt.

Application: It is used in the construction of the railway from Chengdu City to Zigong City in southwest China’s Sichuan Province.


India is sensitive to and opposes the project due to Nepal’s geographic and economic dependence on India. Historical and cultural factors contribute to India’s sense of pressure and superiority over Nepal. India has previously used trade blockades to exert influence. For Nepal, the railway offers a chance to overcome its landlocked condition and reduce its dependence on India by providing a new trade route with China. This could enhance Nepal’s international standing.


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Pfizer-3S Bio Deal

Pfizer has entered into a licensing agreement with China’s 3S Bio for a cancer drug that utilizes bi-specific antibody technology, targeting PD1 and VEGF. 3S Bio is currently conducting clinical trials for this drug in China, focusing on non-small cell lung cancer, colorectal cancer, and gynecological tumors. Pfizer will pay 3S Bio $1.25 billion upfront and potentially up to $4.8 billion for the rights to develop and sell the drug outside of China.


SSGJ-707 is an investigational bispecific antibody developed by China’s 3SBio (specifically Sunshine Guojian Pharmaceutical, a subsidiary). It has recently garnered significant attention due to Pfizer’s exclusive global licensing agreement (excluding China) for its development, manufacturing, and commercialization.

Mechanism of Action: SSGJ-707 has a dual-action mechanism. It simultaneously blocks:

PD-1 (Programmed Death-1): This is an immune checkpoint protein. By blocking PD-1, the drug aims to “unleash” the body’s immune system, allowing T cells to better recognize and fight cancer cells.

VEGF (Vascular Endothelial Growth Factor): This protein plays a crucial role in angiogenesis, the formation of new blood vessels that tumors need to grow and spread. By inhibiting VEGF, SSGJ-707 aims to “starve” tumors of their blood supply. This dual targeting is designed to enhance anti-tumor immunity while also disrupting the tumor’s vascular network, offering a potentially more comprehensive attack on cancer than single-agent therapies.

Development Status:

SSGJ-707 is currently undergoing several clinical trials in China.

It has shown promising early efficacy and safety data in various tumor types.

3SBio plans to initiate the first Phase 3 clinical trial in China in 2025 for the first-line treatment of PD-L1 positive advanced non-small cell lung cancer (NSCLC). This Phase 3 trial is designed to head-to-head against Merck’s blockbuster PD-1 inhibitor, Keytruda (pembrolizumab), with primary endpoint data expected by July 2026.

It is also undergoing Phase II studies for other indications, including metastatic colorectal cancer and advanced gynecological tumors.

Indications Under Investigation (in China):

Non-small cell lung cancer (NSCLC)

Metastatic colorectal cancer (mCRC)

Gynecological tumors (e.g., endometrial cancer, ovarian cancer)


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SD90C5 super bulldozer

The SD90C5 is a “super bulldozer” manufactured by Shantui Construction Machinery Co., Ltd.,

Massive Size and Power: It has an operating weight of approximately 106,260 kg (over 100 tons) and is powered by a Cummins QST30 engine, delivering 708 kW (950 hp) at 2100 rpm. This makes it one of the largest and most powerful bulldozers in the world.

Advanced Intelligence: It incorporates cutting-edge technology including:

5G-powered remote operation system: Allows for remote control, which is crucial for operating in hazardous environments.

GPS navigation: For precise control and operations.

Onboard AI: Enables autonomous or minimally guided execution of complex tasks.

Intelligent diagnostic system: Monitors various parameters in real-time.

Robust Design: Features a heavy-duty chassis, K-type elastic suspension for excellent ground adaptability, and a strong U-shaped or semi-U blade (with a capacity of 39 m³) and a single-tooth ripper.

Operator Comfort and Safety: The ergonomic and integrally sealed cab provides a large space, excellent vision, and effectively isolates noise, meeting EU regulations for noise levels. It also includes a high-power A/C and heating system.

Ease of Maintenance: Designed with a modular structure, openable side hoods, and centralized layout of filters to facilitate easy repairs and maintenance. All lubricating and maintenance points are directed to the outer side of the machine for convenience.

Fuel Efficiency: Features a hydraulic torque converter with a locking function that allows for conversion between hydraulic and mechanical modes, optimizing fuel consumption.

Applications:

The SD90C5 is designed for heavy-duty operations in extremely harsh conditions, including:

Large-scale mining: Ideal for blasting replacement, stripping rock and coal seams.

Dump construction: Efficiently handles the movement of large volumes of material.

Road building and correction: Capable of extensive earthmoving and grading.

Quarrying and heavy industry factories.

Hazardous environments: Its remote control capability makes it suitable for areas affected by earthquakes, landslides, or requiring radioactive cleanup.

China’s Belt and Road Initiative: Used in challenging environmental projects within this initiative.

Sale price: US$1.4 mln.

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Inner Mongolia Yimin open-pit coal mine industrial automation

The Inner Mongolia Yimin open-pit coal mine in China has recently become the site of a groundbreaking development in industrial automation: the launch of a fleet of 100 Huaneng Ruichi driverless electric mining trucks. This initiative marks a significant leap forward in safe, intelligent, and zero-emission coal mining, powered by Huawei’s cutting-edge AI 5G-Advanced (5G-A) and cloud technology.

This project is a collaborative effort involving China Huaneng Group (specifically its subsidiary Huaneng Inner Mongolia Eastern Energy), Xuzhou Construction Machinery Group (XCMG), Huawei Technologies Co., Ltd., and State Grid Smart Internet of Vehicles Co., Ltd.

World’s Largest Single Deployment: With 100 trucks, this is touted as the world’s largest single deployment of driverless electric mining trucks.

First 5G-A Powered Open-Pit Mine: The Yimin mine is the first open-pit mine globally to utilize 5G-A technology for large-scale vehicle-cloud-network synergy.

Fully Electric and Zero-Emission: The Huaneng Ruichi trucks are entirely electric, aligning with China’s push for green and intelligent coal mining. They are reportedly powered by solar-generated green electricity, and the fleet is expected to replace over 15,000 tons of diesel fuel and reduce carbon dioxide emissions by 48,000 tons annually.

Enhanced Efficiency and Safety:

The autonomous trucks are claimed to deliver 120% of the comprehensive operational efficiency of manually driven trucks.

They are designed without a driver’s cabin, directly addressing safety concerns by removing human personnel from hazardous mining environments, especially crucial in extreme conditions.

Huawei’s Commercial Vehicle Autonomous Driving Cloud Service (CVADCS) uses real-time crowdsourced mapping and robust AI algorithms to optimize routes, minimize wait times, and maximize fleet productivity through real-time collaborative operations. It also adapts to real-time variables like weather, ground stability, and machinery wear.

Robust Connectivity: The 5G-A network provides a consistent uplink speed of 500 Mbps with a latency of just 20 milliseconds, vital for real-time data processing, HD video backhaul for remote monitoring, and seamless cloud-based fleet management for 24/7 autonomous operation. This connectivity addresses the challenges of harsh and complex terrain where traditional fiber deployment is impractical.

Extreme Condition Operation: Each truck can carry a payload of 90 metric tons and is engineered to operate reliably in extreme cold, withstanding temperatures as low as −40 C. They are also built to handle the rough conditions of open-pit mines, including heavy vibration, bumps, and impact.

Advanced Technologies: Beyond 5G-A and AI, the trucks utilize cloud computing, intelligent battery swapping, and high-precision mapping. The battery swapping system allows for quick changes (under six minutes for a full swap), eliminating downtime associated with long charging times.

Future Expansion: Plans are already in motion to scale operations, with the 5G-A infrastructure expected to eventually support more than 300 autonomous trucks operating 24/7 at the Yimin mine by 2028. This aligns with China’s broader goal for automated mining trucks nationwide, with projections to exceed 5,000 units by the end of 2025 and reach 10,000 by 2026.

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