On 24 January, scientists at the Institute of Neuroscience (ION) in Shanghai reported that they had used gene-editing to disable a gene in macaque monkeys (Macaca fascicularis) that is crucial to their sleep–wake cycle. The scientists then cloned one of those monkeys to produce five primates with almost identical genes.
It is the first time that researchers have cloned a gene-edited monkey and proof of principle for the researchers’ plan to create populations of genetically identical primates that they say will revolutionize biomedical research. Some of the researchers are part of the new International Centre for Primate Brain Research, which has the goal of creating such populations and received government funding in November.
In Europe and the US, non-human-primate research increasingly faces regulatory hurdles, costs and bioethical opposition. This stands in contrast to China; the country’s 2011 five-year plan set primate disease models as a national goal. The science ministry followed up by investing 25 million yuan (US$3.9 million) into the endeavour in 2014.